We will describe the relationship and pathophysiology of lifestyle habits in the development of cardiovascular disease and cancer and of its risk factors. We will discuss the latest evidenced-based research of whole food, plant-based dietary patterns, exercise, and others in treatment of hypertension and hyperlipidemia, coronary artery disease and cancers. We will teach specific methods to implement lifestyle changes during patient clinic, to utilize team-based approaches with other health care team members, and to collect and monitor long term data to continue successful progress in managing cardiovascular risk factors, coronary artery disease and cancer.